Clinical Trial Performance Metrics 101

Clinical trial performance metrics are among the most powerful tools for assessing progress, decision making, and measuring the strength of evidence used in clinical trials. These metrics are vital for both sponsors and regulatory authorities to make informed decisions about continuing a clinical trial, modifying the trial protocol, selecting the sample size for statistical power, or terminating a study early. These metrics clarify a trial’s performance expectations regarding patient recruitment and retention, which drives both cost-effectiveness and efficiency.  This is called the "critical path" in the drug development industry (i.e., when a clinical trial starts and ends, how long it takes). As the number of clinical trials increase year after year, planning and monitoring is more important than ever. What Are Clinical Trial Metrics?Clinical trial performance metrics are the numbers used to measure the performance of a clinical research team. This includes site patient accrual, site staff compliance with study procedures, site accuracy in data entry, and site retention rates. Sites are measured based on these metrics so that researchers can determine whether they are being effective.The Importance of Measuring Site PerformanceClinical research organizations (CROs) rely on clinical trial data to make decisions about effective sites. Sites that do not meet acceptable performance levels may be dropped from studies or added to the list of sites that are excluded from ongoing study selection processes. Before being considered for future work, a site must prove itself to be effective at managing the clinical trial.How to Measure Site PerformanceSite performance is generally measured by researchers on three core metrics: 1) patient enrollment rate, 2) data accuracy, and 3) retention/attrition rate. All three are critical for developing an accurate picture of whether your clinic is meeting its recruitment goals.1. Patient Enrollment RateIn the fast-paced world of clinical trials, speed is essential. The faster a site…

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Adaptive Research Announces a Collaboration with American Molecular Imaging to Add Nearly 500 Physicians to its Growing Research Network

San Francisco, Calif., March 15, 2022 – Adaptive Research Inc., an integrated clinical trial site organization with a unique purpose to democratize clinical trials by integrating community physicians into the clinical trial process, today announced that American Molecular Imaging has joined the Adaptive Research network to generate greater access to clinical trials and provide a path to market for groundbreaking medical products.Pharmaceutical companies and clinical research organizations (CROs) on the Adaptive Research network will be able to engage AMI partner imaging locations, enabling these sponsors to select study sites with eligible patients for investigative trials, and to pursue answers to clinical questions with de-identified patient data in the United States. With preferred access to nearly 500 specialty trained radiologists, AMI brings a level of imaging expertise that is unmatched by most radiology groups.“AMI is a key element of our strategy to improve access to clinical trials for patients in need of innovative therapies,” said Deepak Behera, MD, President and Chief Executive Officer of Adaptive Research. “This relationship between Adaptive Research and AMI represents a great example of innovation in the healthcare sector. Our collaboration will increase opportunities for domestic and global pharmaceutical and biotech companies to conduct clinical trials with improved efficiency, as well as improve the local research capabilities and contributions of our general practitioners.”Jaideep S. Sohi, MD, President and Founder, American Molecular Imaging, added, “Our reputation and success are attributed to our patient centric approach focused on customer response, access to radiologists, and fast report turnaround by highly trained and experienced subspecialty radiologists. We are excited to partner with Adaptive Research to broaden our service offering with access to future clinical trials.”About American Molecular Imaging Established in 2012, American Molecular Imaging (AMI) is a physician owned and managed full-line provider of specialized professional radiology interpretation services. At AMI, the foundational goal…

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Adaptive Research Expands Operations Team to Position the Company for Growth in 2022

San Francisco, CA, March 14, 2022 – Adaptive Research, an integrated clinical trial site organization with a unique purpose to democratize clinical trials by integrating community physicians into the clinical trial process, announced today the addition of Christine Wong, MD as Director, External Affairs; and Claude Nguyen, MD as Director, Clinical Informatics to the Company’s operations teams.“We are pleased to welcome Drs. Wong and Nguyen to our team as their combined healthcare, clinical trial, and technology expertise will expand our capabilities and position Adaptive Research for significant growth this year,” said Deepak Behera, MD, President & Chief Executive Officer. “In his career, Claude has worked to expand telemedicine to high-need rural areas in the most cost-effective manner possible while preserving high-quality care. Christine’s telemedicine experience along with her ability to foster collaboration across disciplines and geographies will expand our sponsor and physician network.”Dr. Behera, concluded, “In 2021, we increased the number of physicians in our network to over 350,000 patient lives in order to help life science companies tap into a larger, undiluted patient pool from community clinics for their clinical trials. We look forward to the contribution from these experienced professionals as we bridge the divide between technology and healthcare and carry forward our momentum into 2022.”Biographies:Christine Wong, MDConsultant Director, External AffairsDr. Wong is a triple board-certified neurologist (Neurology, Vascular Neurology, Neurocritical care) with over 12 years of clinical, quality, and research experience. She is a founding physician partner of Bay Area Neurospecialists Group, which partners with AHMC Seton Medical Center and at Kentfield Rehabilitation Hospital, to provide exceptional care individuals with brain injury. Previously, Dr. Wong was Attending Physician, Vascular Neurology and Neurocritical Care at Sutter Health California Pacific Medical Center (CPMC) for 9 years and served as Co-Chair of Neurosciences Quality Improvement Committee for 7 years. In this role, Dr. Wong’s keen collaborative skills fostered teamwork across disciplines…

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Adaptive Research and UBERDOC Announce Collaboration to Expand Clinical Trial Access to Physicians and Patients

San Francisco, Ca., March 8, 2022 – Adaptive Research, an integrated clinical trial site organization with a unique purpose to democratize clinical trials by integrating community physicians into the clinical trial process, and UBERDOC, the leading direct-to-consumer digital healthcare platform, announced today a collaboration to expand clinical trial access to the physicians and clinical trial sites in the UBERDOC network.With this collaboration Adaptive Research will be provided access to the UBERDOC physicians who are qualified to be clinical trial investigators. Adaptive Research will also have access to the UBERDOC clinics, hospitals, and other similar institutions which have the facilities and staff necessary to run a clinical trial.In turn, UBERDOC will be able to offer Adaptive Research’s clinical trial opportunities to the over 3,000 board-certified physicians and specialists in their network. Adaptive Research offers pharmaceutical companies and clinical research organizations (CROs) a wide range of solutions to improve their clinical trial recruitment, and these companies will now have patient-access through the UBERDOC physician network.“We are excited to partner with UBERDOC to expand our network of physicians, clinics and hospitals,” said Deepak Behera, MD, President & Chief Executive Officer of Adaptive Research. “UBERDOC’s mission to decentralize the healthcare treatment landscape perfectly synergizes with our goal to bring clinical trials to the broader community. We look forward to working together to generate greater access to clinical trials and provide a path to market for groundbreaking medical products.”Paula Muto, MD, FACS, CEO and founder of UBERDOC, added, “As the leading direct-to-consumer digital healthcare platform, we are committed to connecting physicians and patients with the care they need. This partnership with Adaptive Research will alert our physician network of certain clinical trials and give them the support to participate in the trial. This is another way UBERDOC is changing the healthcare status quo by meeting patients…

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